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[Superacute xenogenic rejection: attempted treatment with anti-idiotypic antibodies].

Authors
  • 1
Type
Published Article
Journal
La Presse Médicale
0755-4982
Publisher
Elsevier
Publication Date
Volume
21
Issue
41
Pages
1945–1946
Identifiers
PMID: 1294946
Source
Medline

Abstract

Heart xenotransplantation in the guinea-pig to rat model, a highly discordant combination, is invariably followed by a hyperacute rejection of the graft. Preformed IgMs were shown to be responsible for the destruction of the graft by stimulating the complement cascade. We tried to inhibit preformed antibodies, before transplantation, by inducing anti-idiotypic antibodies using autologous Fab' mu specific for guinea-pig endothelial cells. This treatment seems to exert a neutralizing effect on xenogeneic hyperimmunization, against guinea-pig endothelial cells but not against preformed anti-guinea-pig antibodies.

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