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Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis.

Authors
  • Ring, F A
  • Hershfield, N B
  • Machin, G A
  • Scott, R B
Type
Published Article
Journal
Canadian Medical Association journal
Publication Date
Jul 01, 1984
Volume
131
Issue
1
Pages
43–45
Identifiers
PMID: 6145516
Source
Medline
License
Unknown

Abstract

A diagnosis of idiopathic ulcerative colitis was made in a previously healthy 9-year-old boy. Symptoms persisted despite therapy with sulfasalazine, 50 mg/kg daily, but they eventually responded to treatment with parenteral nutrition and prednisone, 40 mg daily. Metronidazole was also given to eradicate persistent Dientamoeba fragilis from the stools. The symptoms resolved over 3 weeks, and the daily dose of prednisone was tapered. On two subsequent occasions a challenge with sulfasalazine caused an immediate recurrence of loose, blood-streaked stools and of nonspecific histologic features of ulcerative colitis, which resolved when the sulfasalazine was discontinued.

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