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Sugar amino acid containing somatostatin analogues that induce apoptosis in both drug-sensitive and multidrug-resistant tumor cells.

Authors
  • Gruner, S A
  • Kéri, G
  • Schwab, R
  • Venetianer, A
  • Kessler, H
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Nov 15, 2001
Volume
3
Issue
23
Pages
3723–3725
Identifiers
PMID: 11700122
Source
Medline
License
Unknown

Abstract

[carbohydrate structure--see text] Resistance to chemotherapy has become a major problem in cancer therapy. The new sugar amino acid (SAA) containing somatostatin analogues presented possess antiproliferative and apoptotic activity against both multidrug-resistant and drug-sensitive hepatoma carcinoma cells. Synthesis, design, and biological evaluation of the cyclic analogues and of the furanoid SAA used will be discussed. Four analogues have IC(50) values in the low microM range, making them promising leads for chemotherapeutic drugs against multidrug-resistant carcinoma.

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