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Sufficient numbers of anti-tumor T cells is a condition of maximal efficacy of anti-hypoxia-A2-adenosinergic drugs during cancer immunotherapy.

Authors
  • Sitkovsky, Michail V1
  • 1 New England Inflammation and Tissue Protection Institute, Department of Pharmaceutical Sciences and Biology, Northeastern University, Boston, MA 02115, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Current opinion in pharmacology
Publication Date
Aug 27, 2020
Volume
53
Pages
98–100
Identifiers
DOI: 10.1016/j.coph.2020.07.011
PMID: 32861959
Source
Medline
Language
English
License
Unknown

Abstract

The anti-hypoxia-A2-Adenosinergic immunotherapies of cancer emerged as the only available now approach to enable the tumor rejection in those progressing cancer patients that are refractory to all other current treatments. Several different classes of drugs are offered to inhibit the Hypoxia-HIF-1alpha-mediated and extracellular adenosine-A2A adenosine receptor-mediated immunosuppressive signaling in tumor microenvironment. It is suggested that the most promising treatments must include the blockade of cAMP-elevating A2A adenosine receptors and the elimination of hypoxia in tumors by oxygenation agents and hyperoxic breathing. The observations in ongoing clinical trials support this conclusion. Copyright © 2020. Published by Elsevier Ltd.

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