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Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow-cooling cryopreservation.

Authors
  • Coticchio, G
  • De Santis, L
  • Rossi, G
  • Borini, A
  • Albertini, D
  • Scaravelli, G
  • Alecci, C
  • Bianchi, V
  • Nottola, S
  • Cecconi, S
Type
Published Article
Journal
Human reproduction (Oxford, England)
Publication Date
Jul 01, 2006
Volume
21
Issue
7
Pages
1771–1776
Identifiers
PMID: 16549422
Source
Medline
License
Unknown

Abstract

Partial disruption of the MII spindle and associated chromosomes accompanies inadequate cryopreservation during slow cooling. However, protocols adopting higher sucrose concentration in the freezing solution promote the retention of an intact chromosome segregation apparatus comparable in incidence to freshly collected oocytes.

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