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Sucralfate and Methylprednisolone Enemas in Active Ulcerative Colitis (A Prospective, Single-Blind Study)

Authors
  • Wright, John P.
  • Winter, Trevor A.
  • Candy, Sally
  • Marks, In
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Sep 01, 1999
Volume
44
Issue
9
Pages
1899–1901
Identifiers
DOI: 10.1023/A:1018863210931
Source
Springer Nature
Keywords
License
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Abstract

In order to investigate the role of sucralfatein active ulcerative colitis, 60 patients wererandomized to receive either sucralfate enemas (20 g/100ml) or methylprednisolone enemas (20 mg/100 ml). The enemas were administered twice daily for oneweek, and then once daily for three weeks. Clinicalevaluation was documented at entry and at two weeks andfour weeks. The sigmoidoscopic appearance of the rectal mucosa was scored, and rectal biopsiestaken at entry and at four weeks. Results indicatedsimilar reduction in diarrhea and rectal bleeding at twoweeks and at four weeks. Sigmoidoscopy demonstrated similar significant improvement in themacroscopic appearance of the rectal mucosa in bothgroups (8.28 to 6.20 in sucralfate group, P < 0.02;and 8.72 to 6.36 in the methylprednisolone treatedgroup, P < 0.04). Histologic assessment, likewise,showed similar improvements in the two groups. Thisstudy indicates that sucralfate enemas may be useful inthe treatment of ulcerative proctosigmoiditis.

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