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Successful unrelated donor cord blood transplantation for chronic granulomatous disease.

Authors
  • Jaing, Tang-Her1
  • Lee, Wen I
  • Cheng, Po-Jen
  • Chen, Shih-Hsiang
  • Huang, Jing-Long
  • Soong, Yung-Kuei
  • 1 Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan. , (Taiwan)
Type
Published Article
Journal
International Journal of Hematology
Publisher
Springer-Verlag
Publication Date
May 01, 2010
Volume
91
Issue
4
Pages
670–672
Identifiers
DOI: 10.1007/s12185-010-0537-5
PMID: 20224873
Source
Medline
License
Unknown

Abstract

This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 x 10(7)/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 x 10(9)/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

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