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Successful treatment of a Streptococcus pneumoniae- associated haemolytic uraemic syndrome by eculizumab

Authors
  • Jeantet, Guillaume1
  • Pernin, Vincent1
  • Brunot, Vincent2
  • Roccabianca, Arnaud1
  • Macombe, Anouk1
  • Szwarc, Ilan1
  • Klouche, Kada2
  • Loirat, Chantal3
  • Mourad, Georges1
  • Frémeaux-Bacchi, Véronique4
  • Le Quintrec, Moglie1
  • 1 Department of Nephrology and Kidney Transplantation, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
  • 2 Critical Care Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
  • 3 Department of Pediatric Nephrology, Hôpital Universitaire Robert Debré, Paris, France
  • 4 Laboratory of Immunology, Hôpital Européen Georges Pompidou, Paris, France
Type
Published Article
Journal
Clinical Kidney Journal
Publisher
Oxford University Press
Publication Date
Mar 20, 2018
Volume
12
Issue
1
Pages
106–109
Identifiers
DOI: 10.1093/ckj/sfy019
PMID: 30746136
PMCID: PMC6366139
Source
PubMed Central
Keywords
License
Unknown

Abstract

Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.

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