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Successful treatment of juvenile generalized pustular psoriasis with infliximab therapy: two case reports

Authors
  • Lu, Jiajing
  • Li, Ying
  • Yu, Ning
  • Chen, Fujuan
  • Ding, Yangfeng
  • Yi, Xuemei
Type
Published Article
Journal
The Journal of International Medical Research
Publisher
SAGE Publications
Publication Date
Mar 27, 2020
Volume
48
Issue
3
Identifiers
DOI: 10.1177/0300060520912091
PMID: 32216562
PMCID: PMC7132563
Source
PubMed Central
Keywords
License
Unknown

Abstract

Juvenile generalized pustular psoriasis is a rare, severe type of psoriasis that can be life-threatening. Thus far, treatment for juvenile generalized pustular psoriasis has been challenging, and no standardized guidelines are available. Here, we describe two Chinese boys with juvenile generalized pustular psoriasis who were successfully treated with infusions of infliximab. During 12 months of follow-up, no recurrence or exacerbation was observed in either patient. Herpes zoster was observed as an adverse effect in one patient, following the initial infusion of infliximab; the other patient did not experience any adverse reaction. Although infliximab is effective therapy for patients with juvenile generalized pustular psoriasis, there is a need for close monitoring of adverse effects in these patients.

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