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Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia.

Authors
  • Yuda, Junichiro
  • Kato, Koji
  • Kikushige, Yoshikane
  • Ohkusu, Kiyofumi
  • Kiyosuke, Makiko
  • Sakamoto, Keiji
  • Oku, Seido
  • Miyake, Noriko
  • Kadowaki, Masako
  • Iino, Tadafumi
  • Tanimoto, Kazuki
  • Takenaka, Katsuto
  • Iwasaki, Hiromi
  • Miyamoto, Toshihiro
  • Shimono, Nobuyuki
  • Teshima, Takanori
  • Akashi, Koichi
Type
Published Article
Journal
Internal medicine (Tokyo, Japan)
Publication Date
Jan 01, 2014
Volume
53
Issue
10
Pages
1087–1091
Identifiers
PMID: 24827491
Source
Medline
License
Unknown

Abstract

Zygomycosis is a lethal and invasive mold infection that is often associated with hematological malignancies. The keys for successful treatment include making a rapid diagnosis and appropriately administering antifungal agents. We herein report the early diagnosis of a case of zygomycosis in a patient with acute myeloid leukemia using a deoxyribonucleic acid sequence analysis. We successfully performed allogeneic hematopoietic stem cell transplantation with the use of high-dose liposomal amphotericin B and granulocyte transfusion.

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