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Successful treatment of COVID‐19 infection with convalescent plasma in B‐cell‐depleted patients may promote cellular immunity

Authors
  • Kremer, Andreas E.1, 2
  • Kremer, Anita N.3
  • Willam, Carsten3
  • Völkl, Simon3
  • Verhagen, Johan3
  • Achenbach, Susanne3
  • van der Meijden, Edith D.3
  • Lang, Vanessa3
  • Aigner, Michael3
  • Maier, Clara4
  • Tenbusch, Matthias4
  • Korn, Klaus4
  • Lutzny‐Geier, Gloria3
  • Spoerl, Silvia3
  • Strauß, Richard2
  • Vetter, Marcel2
  • Überla, Klaus4
  • Neurath, Markus F.2
  • Mackensen, Andreas3
  • Schiffer, Mario3
  • And 1 more
  • 1 University Hospital Zürich, Switzerland , (Switzerland)
  • 2 University Hospital Erlangen and Friedrich‐Alexander‐University of Erlangen‐Nürnberg, Germany , (Germany)
  • 3 University Hospital Erlangen and Friedrich‐Alexander‐University Erlangen‐Nürnberg, Germany , (Germany)
  • 4 University Hospital Erlangen, Friedrich‐Alexander‐University Erlangen‐Nürnberg, Germany , (Germany)
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 03, 2021
Identifiers
DOI: 10.1002/eji.202149277
PMID: 34350584
PMCID: PMC8420096
Source
PubMed Central
Keywords
Disciplines
  • Immunity to infection
  • Short Communication
  • Clinical
License
Unknown
External links

Abstract

Treatment of B‐cell depleted patients suffering from COVID‐19 with convalescent plasma led to viral clearance and was followed by an increase in peptide‐specific CD4+ T‐cells suggesting that transient antibody titers promoted specific cellular immunity in these patients.

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