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Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow.

Authors
  • Salvatierra, O Jr
  • Singh, T
  • Shifrin, R
  • Conley, S
  • Alexander, S
  • Tanney, D
  • Lemley, K
  • Sarwal, M
  • Mackie, F
  • Alfrey, E
  • Orlandi, P
  • Zarins, C
  • Herfkens, R
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Oct 15, 1998
Volume
66
Issue
7
Pages
819–823
Identifiers
PMID: 9798687
Source
Medline
License
Unknown

Abstract

This study is the first to quantitatively document the blood flow changes occurring after ASK transplantation in infants. There was a greater than two-fold increase in aortic blood flow after ASK transplantation, and this increase was sustained for at least 4 months and appeared to be driven by the blood flow demand of the ASK. However, actual posttransplant renal artery blood flow was significantly less than normal renal artery flow. Our study suggests that aggressive intravascular volume maintenance may be necessary to achieve and maintain optimum aortic blood flow, so as not to further compromise posttransplant renal artery flow and to avoid low-flow states that could induce acute tubular necrosis, vascular thrombosis, or primary nonfunction.

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