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Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma

Authors
  • Zhang, Li-Bo1, 2
  • Pang, Rong-Rong1, 2
  • Qiao, Qing-Hua3, 4
  • Wang, Zhi-Hua4, 5, 6
  • Xia, Xin-Yi1, 4, 6
  • Wang, Chang-Jun6, 7
  • Xu, Xiao-Li6, 8
  • 1 Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, the First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu, 210002, China , Nanjing (China)
  • 2 Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing, Jiangsu, 210003, China , Nanjing (China)
  • 3 Medical and Technical Support Department, Pingdingshan Medical District, the 989th Hospital, Pingdingshan, Henan, 467000, China , Pingdingshan (China)
  • 4 Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, Wuhan, Hubei, 430100, China , Wuhan (China)
  • 5 Department of Laboratory Medicine & Blood Transfusion, the 907th Hospital, Nanping, Fujian, 350702, China , Nanping (China)
  • 6 Joint Expert Group for COVID-19, Wuhan Huoshenshan Hospital, Wuhan, Hubei, 430100, China , Wuhan (China)
  • 7 Center for Disease Control and Prevention of PLA, No. 20 Dongda Street, Fengtai District, Beijing, 100071, China , Beijing (China)
  • 8 Nanjing University School of Medicine, No. 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China , Nanjing (China)
Type
Published Article
Journal
Military Medical Research
Publisher
Springer Nature
Publication Date
Sep 23, 2020
Volume
7
Issue
1
Identifiers
DOI: 10.1186/s40779-020-00273-5
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundGastrointestinal symptoms are not rare among coronavirus disease 2019 (COVID-19) patients, but there have been no reports regarding convalescent plasma therapy for the recovery of gastrointestinal problems in COVID-19 patients.Case presentationWe present two cases of patients with COVID-19-associated recurrent diarrhea and positive fecal occult blood who successfully recovered after a one-time convalescent plasma administration.ConclusionWhen COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment, alternative therapy with convalescent plasma administration may be considered.

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