Affordable Access

Successful high-dose intravenous cytarabine treatment of parenchymal brain involvement from malignant lymphoma.

Authors
  • Frick, J C
  • Hansen, R M
  • Anderson, T
  • Ritch, P S
Type
Published Article
Journal
Archives of Internal Medicine
Publisher
American Medical Association
Publication Date
Apr 01, 1986
Volume
146
Issue
4
Pages
791–792
Identifiers
PMID: 3963961
Source
Medline
License
Unknown

Abstract

A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, with normalization of the brain computed tomographic scan. This case further demonstrates the ability of high-dose cytarabine to penetrate the blood-brain barrier and achieve therapeutic drug concentrations in the central nervous system, an area that might otherwise remain a pharmacologic sanctuary for tumor cells.

Report this publication

Statistics

Seen <100 times