Affordable Access

Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2.

Authors
  • Ong, S H
  • Goh, K C
  • Lim, Y P
  • Low, B C
  • Klint, P
  • Claesson-Welsh, L
  • Cao, X
  • Tan, Y H
  • Guy, G R
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Aug 23, 1996
Volume
225
Issue
3
Pages
1021–1026
Identifiers
PMID: 8780727
Source
Medline
License
Unknown

Abstract

In Swiss 3T3 fibroblasts, basic fibroblast growth factor (bFGF) stimulates the unique tyrosine phosphorylation of a protein complex around 90 kDa, as ascertained by high resolution 2-D PAGE and anti-phosphotyrosine blotting. The majority of this complex consists of the protein(s) designated previously as SNT (suc1-associated neurotrophic factor target). Tyrosine phosphorylated SNT binds to both p13suc1 protein and the SH2 domain of Grb2. Binding of SNT to Grb2 is likely to be mediated through the consensus binding motif, pYXN, on SNT. The binding of SNT to p13suc1 is independent of the pYXN motif. Tyrosine phosphorylated SNT is localised in the plasma membrane where it could form a complex with Grb2 and Sos, enabling the initiation of a novel FGF-specific signalling pathway.

Report this publication

Statistics

Seen <100 times