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Subtypes of cytotoxic lymphocytes and natural killer cells infiltrating cancer nests correlate with prognosis in patients with vulvar squamous cell carcinoma.

Authors
  • Sznurkowski, Jacek Jan1
  • Zawrocki, Anton
  • Biernat, Wojciech
  • 1 Department of Oncological Surgery, The Medical University of Gdańsk, ul. Smoluchowskiego 17, 80-214, Gdańsk, Poland, [email protected] , (Poland)
Type
Published Article
Journal
Cancer Immunology Immunotherapy
Publisher
Springer-Verlag
Publication Date
Mar 01, 2014
Volume
63
Issue
3
Pages
297–303
Identifiers
DOI: 10.1007/s00262-013-1511-x
PMID: 24368339
Source
Medline
License
Unknown

Abstract

The combined cytotoxicity of innate and adaptive immune effectors infiltrating cancer nests (IE GrB+) predicts an improved clinical outcome among non-metastatic vSCC patients. The functional status of prognostic IE CD56+ infiltrates in immune escaped (metastatic) tumors requires further investigation.

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