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Subtype and pathway specific responses to anticancer compounds in breast cancer.

Authors
  • Lm, Heiser
  • A, Sadanandam
  • Wl, Kuo
  • Sc, Benz
  • Tc, Goldstein
  • S, Ng
  • Wj, Gibb
  • Nj, Wang
  • S, Ziyad
  • F, Tong
  • N, Bayani
  • Z, Hu
  • Ji, Billig
  • A, Dueregger
  • S, Lewis
  • L, Jakkula
  • Je, Korkola
  • S, Durinck
  • F, Pepin
  • Y, Guan
  • And 23 more
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Volume
109
Issue
8
Pages
2724–2729
Identifiers
DOI: 10.1073/pnas.1018854108
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.

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