Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.
- Authors
- Type
- Published Article
- Journal
- Journal of clinical microbiology
- Publication Date
- Jun 01, 2004
- Volume
- 42
- Issue
- 6
- Pages
- 2847–2849
- Identifiers
- PMID: 15184489
- Source
- Medline
- License
- Unknown
Abstract
We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.