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Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.

Authors
  • Gaudy, Catherine
  • Moreau, Alain
  • Brunet, Sylvie
  • Descamps, Jean-Michel
  • Deleplanque, Pascale
  • Brand, Denys
  • Barin, Francis
Type
Published Article
Journal
Journal of clinical microbiology
Publication Date
Jun 01, 2004
Volume
42
Issue
6
Pages
2847–2849
Identifiers
PMID: 15184489
Source
Medline
License
Unknown

Abstract

We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.

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