Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.

Catherine Gaudy; Alain Moreau; Sylvie Brunet; Jean-Michel Descamps; Pascale Deleplanque; Denys Brand; Francis Barin

Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.

Authors

Gaudy, Catherine
Moreau, Alain
Brunet, Sylvie
Descamps, Jean-Michel
Deleplanque, Pascale
Brand, Denys
Barin, Francis

Type

Published Article

Journal

Journal of clinical microbiology

Publication Date

Jun 01, 2004

Volume

42

Issue

6

Pages

2847–2849

Identifiers

PMID: 15184489

Source

Medline

License

Unknown

Abstract

We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/15184489

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