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Substrates of PHD

Authors
  • Lee, Frank S.1
  • 1 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Type
Published Article
Journal
Cell metabolism
Publication Date
Oct 01, 2019
Volume
30
Issue
4
Pages
626–627
Identifiers
DOI: 10.1016/j.cmet.2019.08.008
PMID: 31577931
PMCID: PMC7454164
Source
PubMed Central
License
Unknown

Abstract

The discovery of prolyl hydroxylase domain proteins (PHDs) as key enzymes in the hypoxia inducible factor (HIF) pathway has been followed by reports of a multitude of non-HIF substrates of PHD. Reporting in eLife , Cockman et al. (2019) find a surprising lack of detectable PHD activity toward any of them.

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