Affordable Access

deepdyve-link
Publisher Website

Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme.

Authors
  • Celis, Arianna I1
  • DuBois, Jennifer L2
  • 1 Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States. , (United States)
  • 2 Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
May 15, 2015
Volume
574
Pages
3–17
Identifiers
DOI: 10.1016/j.abb.2015.03.004
PMID: 25778630
Source
Medline
Keywords
License
Unknown

Abstract

PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20 protein families sharing a common α,β-barrel domain. Of these, six different groups bind heme inside the barrel's interior, using it alternately as a cofactor, substrate, or product. Focusing on these six, an integrated picture of structure, sequence, taxonomy, and mechanism is presented here, detailing how a single structural motif might be able to mediate such an array of functions with one of nature's most important small molecules.

Report this publication

Statistics

Seen <100 times