Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme.
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States.
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States. Electronic address: [email protected]
- Published Article
Archives of Biochemistry and Biophysics
- Publication Date
May 15, 2015
PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20 protein families sharing a common α,β-barrel domain. Of these, six different groups bind heme inside the barrel's interior, using it alternately as a cofactor, substrate, or product. Focusing on these six, an integrated picture of structure, sequence, taxonomy, and mechanism is presented here, detailing how a single structural motif might be able to mediate such an array of functions with one of nature's most important small molecules.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/25778630