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Substitution of arginine for glycine at position 847 in the triple-helical domain of the alpha 1 (I) chain of type I collagen produces lethal osteogenesis imperfecta. Molecules that contain one or two abnormal chains differ in stability and secretion.

Authors
Type
Published Article
Journal
The Journal of biological chemistry
Publication Date
Volume
265
Issue
30
Pages
18628–18633
Identifiers
PMID: 2211725
Source
Medline

Abstract

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