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Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus.

Authors
  • Demmers, Martijn W H J
  • Baan, Carla C
  • Janssen, Malou
  • Litjens, Nicolle H R
  • Ijzermans, Jan N M
  • Betjes, Michiel G
  • Weimar, Willem
  • Rowshani, Ajda T
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 15, 2014
Volume
97
Issue
1
Pages
47–55
Identifiers
DOI: 10.1097/01.TP.0000435697.31148.b2
PMID: 24157471
Source
Medline
License
Unknown

Abstract

Our data show substantial proliferation of TEC-reactive CD4CD28 memory T cells, which are resistant to tacrolimus and everolimus. This phenomenon might play an important mechanistic role during cellular rejection under full immunosuppression.

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