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Substance P-immunoreactive processes on 5HT/SP-immunoreactive medullary cells.

Authors
Type
Published Article
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
13
Issue
4
Pages
559–563
Identifiers
PMID: 6084543
Source
Medline
License
Unknown

Abstract

Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). The punctate SP-immunoreactive processes were present on 5HTI/SPI cells in the raphe nuclei and ventral reticular formation. This close association suggests that activity in bulbospinal 5HT/SP pathways, which can influence sympathetic preganglionic neurons, may be affected by the release of SP in the brainstem.

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