Affordable Access

Access to the full text

Substance P-Immunoreactive Cells in the Ovine Pars Tuberalis

Authors
  • Skinner, Donal C.
  • Lang, A. Lee
  • Pahl, Lindsay
  • Wang, Qi
Type
Published Article
Journal
Neuroendocrinology
Publisher
S. Karger AG
Publication Date
Oct 31, 2008
Volume
89
Issue
1
Pages
3–8
Identifiers
DOI: 10.1159/000167797
PMID: 18974628
Source
Karger
Keywords
License
Green
External links

Abstract

The pars tuberalis (PT) is a distinct subdivision of the anterior pituitary gland that plays a central role in regulating seasonal prolactin release. In sheep, there is compelling evidence that seasonal changes in light, transformed into a melatonin signal, are interpreted by the PT to modulate the release of a factor which affects prolactin release. The identity of this factor(s) is unknown but has been preemptively called ‘tuberalin’. In the present study, we report on an initial immunocytochemical investigation where we have identified that many ovine PT cells are immunoreactive for the tachykinin substance P (SP). Few cells in the pars distalis immunoreact for SP. The SP-immunoreactive cells did not colocalize with β-luteinizing hormone. RT-PCR confirmed the presence of preprotachykinin A mRNA in the PT. We hypothesize that SP, and possibly other preprotachykinin A-derived tachykinins, may play a role in the seasonal regulation of prolactin secretion in sheep.

Report this publication

Statistics

Seen <100 times