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A subset of nondescript axillary lymph node inclusions have the immunophenotype of endosalpingiosis.

Authors
  • Carney, Erin
  • Cimino-Mathews, Ashley
  • Argani, Cynthia
  • Kronz, Joseph
  • Vang, Russell
  • Argani, Pedram
Type
Published Article
Journal
The American Journal of Surgical Pathology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 01, 2014
Volume
38
Issue
12
Pages
1612–1617
Identifiers
DOI: 10.1097/PAS.0000000000000261
PMID: 24921637
Source
Medline
License
Unknown

Abstract

We report 2 cases of bland, otherwise nondescript axillary lymph node inclusions that have the immunophenotype of endosalpingiosis in patients with concurrent invasive breast carcinomas. Neither inclusion demonstrated the classic morphology of endosalpingiosis with admixed ciliated and secretory cells. Rather, both cases were composed of nondescript cuboidal to columnar bland epithelial cells situated within the lymph node capsule. Whereas both inclusions labeled diffusely for estrogen receptor and lacked evidence of a myoepithelial component, both labeled diffusely for PAX8 and WT-1, which distinguished them from their corresponding concurrent primary mammary carcinomas. These findings suggest that a subset of otherwise nondescript axillary lymph node inclusions represent endosalpingiosis and highlight the utility of PAX8 and WT-1 immunohistochemistry in distinguishing these from metastatic well-differentiated ductal carcinoma.

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