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Subsensitivity to substance P in SART-stressed mice.

Authors
  • Hata, T
  • Itoh, E
  • Oyama, R
  • Kawabata, A
  • Kita, T
Type
Published Article
Journal
Japanese journal of pharmacology
Publication Date
Feb 01, 1989
Volume
49
Issue
2
Pages
293–296
Identifiers
PMID: 2471860
Source
Medline
License
Unknown

Abstract

The sensitivity of SART-stressed (repeated cold-stressed) mice to substance P (SP) was studied. The behavioral responses to intrathecal SP in the stressed mice were less marked than those in non-stressed mice. The 50% effective dose of SP, however, did not differ between the 2 groups. Also, the antagonistic effect of intrathecal [D-Pro2, D-Trp7,9]-substance P against SP was not different. These results suggest that SART-stressed mice are subsensitive to exogenous SP and that the number but not the affinity of SP receptors may be altered.

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