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Sublingual methadone for the management of cancer-related breakthrough pain: a pilot study.

Authors
  • Hagen, Neil A
  • Fisher, Kim
  • Stiles, Carla
Type
Published Article
Journal
Journal of palliative medicine
Publication Date
Apr 01, 2007
Volume
10
Issue
2
Pages
331–337
Identifiers
PMID: 17472503
Source
Medline
License
Unknown

Abstract

This model of assessment of breakthrough pain, whereby each episode of pain is treated as a separate data set and multiple discrete episodes of breakthrough pain are assessed every 5 minutes in each patient, appears to be feasible within the cancer pain population. Preliminary results suggest a very rapid onset of relief of breakthrough pain with sublingual methadone when administered at the optimal dose, consistent with a highly favorable early pharmacodynamic profile of methadone administered via this route. Further study is warranted.

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