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Subcutaneously administered antibiotics.

Authors
  • Colin, E1
  • Baldolli, A2
  • Verdon, R2
  • Saint-Lorant, G3
  • 1 Pharmacie centrale, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France. , (France)
  • 2 Service de maladies infectieuses et tropicales, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France. , (France)
  • 3 Pharmacie centrale, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Medecine et maladies infectieuses
Publication Date
May 01, 2020
Volume
50
Issue
3
Pages
231–242
Identifiers
DOI: 10.1016/j.medmal.2019.06.007
PMID: 31300245
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The subcutaneous route is a widely used route of administration in routine clinical practice, particularly in elderly patients, when the intravenous route cannot be used. This review of the literature highlights the lack of randomized studies and the lack of pharmacokinetic data on the use of this route of administration. Three antibiotics administered subcutaneously can be used for severe infections, with acceptable pharmacokinetic and pharmacodynamic data, when the intravenous administration is not possible: ceftriaxone, ertapenem, and teicoplanin. Copyright © 2019 Elsevier Masson SAS. All rights reserved.

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