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Subcutaneous Furosemide in Heart Failure: Pharmacokinetic Characteristics of a Newly Buffered Solution

Authors
  • Sica, Domenic A.
  • Muntendam, Pieter
  • Myers, Rene L.
  • ter Maaten, Jozine M.
  • Sale, Mark E.
  • de Boer, Rudolf A.
  • Pitt, Bertram
Publication Date
Feb 07, 2018
Source
PubMed Central
Keywords
Language
English
License
Unknown
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Abstract

Parenteral diuretics form the cornerstone of decongestion in heart failure. However, parenteral therapy routinely requires emergency room or inpatient care. A novel buffered furosemide formulation with neutral pH was developed to offer “hospital-strength” diuresis for outpatient use, including self-administration at home. Subcutaneous infusion using a biphasic delivery profile resulted in complete bioavailability (99.65%) and equivalent diuresis when compared with intravenous administration. Subcutaneous administration of buffered furosemide was well tolerated with no evidence of any drug-induced skin reactions. Subcutaneous infusion of buffered furosemide in the outpatient setting or home may help to reduce the burden of heart failure.

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