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[Study of X antigen of Salmonella typhi responsible for the production of protective antibody towards chick embryo].

Authors
  • Joyeux, Y
  • Jouin, H
  • Leluc, B
  • Staub, A M
Type
Published Article
Journal
Annales d'immunologie
Publication Date
Jan 01, 1977
Volume
128
Issue
1-2
Pages
221–223
Identifiers
PMID: 848877
Source
Medline
License
Unknown

Abstract

Laboratory animals are not sensitive to human S. typhi strain (O+ Vi+). But the chick embryo is very susceptible to infection by this strain. This property can be used to test protective activity of immuno sera. Several antigenic fractions have been prepared from Ty6S strain (0- Vi+) by washing methods. The " outer layer " of the bacteria is easily removed by NaCl 0,5 M. Injected in rabbits this preparation produces the synthesis of protective antibodies. The active antigen X is spun down with the Vi antigen. The relation of X antigen to Vi antigen is being studied.

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