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Study on the preparation of collagen-modified silk fibroin films and their properties.

Authors
  • Tang, Yin
  • Cao, Chuanbao
  • Ma, Xilan
  • Chen, Chen
  • Zhu, Hesun
Type
Published Article
Journal
Biomedical materials (Bristol, England)
Publication Date
Dec 01, 2006
Volume
1
Issue
4
Pages
242–246
Identifiers
DOI: 10.1088/1748-6041/1/4/010
PMID: 18458412
Source
Medline
License
Unknown

Abstract

Blended films were prepared from a silk fibroin (SF) solution by adding a small amount of type I collagen (<5%). The mechanical properties of the wet films modified by collagen were improved obviously. The elongation at break reached 42%, and the smaller contact angles revealed that modified films had better hydrophilicity. 1% heparin was also added to modify the SF films to further improve the in vitro antithrombogenecity. The internal structure of the modified SF films was investigated with scanning electron microscopy, x-ray diffraction and Fourier transform infrared attenuated total reflection spectroscopy. The result indicates that the addition of a small amount of collagen and heparin did not change their conformation.

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