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Study of Monocytes/Macrophages Stimuli as the Targets of Treating Inflammatory Bone Diseases.

Authors
  • Liu, Yuan1, 2
  • Cao, Yang1, 2
  • Smith, Wanli3
  • He, Baorong1
  • Yan, Liang1
  • 1 Department of Orthopedics, Honghui-hospital, Xi'an Jiaotong University, School of medicine, Xi'an, China. , (China)
  • 2 Medical College of Yan'an University, Yan'an, China. , (China)
  • 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, 600 N. Wolfe St. Baltimore, Maryland, United States. , (United States)
Type
Published Article
Journal
Current drug targets
Publication Date
Jan 01, 2020
Volume
21
Issue
4
Pages
338–343
Identifiers
DOI: 10.2174/1389450120666191015211737
PMID: 31644400
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different cell models could regulate this progress in some aspects. Therefore, in the current review, we summarize several cytokines and cell models, which could lead to inflammatory orthopedic diseases via regulating monocytes and macrophages. In order to extensively explore the potential therapeutic and medicine targets for inflammation-induced bone diseases. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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