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[Study of the membrane oxidative response of phagocytes after treatment with marbofloxacin in healthy cattle].

Authors
  • Spehner, V1
  • Aberlin, S
  • Biichlé, S
  • Seillès, E
  • 1 Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon, France. , (France)
Type
Published Article
Journal
Comptes rendus des seances de la Societe de biologie et de ses filiales
Publication Date
Jan 01, 1996
Volume
190
Issue
5-6
Pages
633–639
Identifiers
PMID: 9074728
Source
Medline
Language
French
License
Unknown

Abstract

In addition to their antibacterial properties, quinolones are capable of modulating the immune response. The aim of this paper was to study the effects of a new fluoro-4-quinolone on the respiratory burst. We evaluated the effects of marbofloxacin on the activation of peripheral phagocytes in non-infected bovines after a 5-day treatment. The immunopharmalogical study measured the chemiluminescence response of phagocytic cells obtained from total blood. Serum cortisol and albumin levels were also measured. Data showed that the treatment with marbofloxacin induced a mild decrease in the oxidative response. There was no significant difference between serum albumin levels of normal values and those of before and after treatment, and the levels of serum cortisol were also not significantly different before and after treatment. These results suggest that marbofloxacin treatment could modulate the inflammatory response of phagocytic cells by counteracting the oxidative burst.

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