A number of prosthetic materials, it may be used to replace facial parts of maxillofacial that lost through disease or trauma. The silicone rubbers it is considered are the best materials in this area. So that, the aim of this research is to study the effect of addition of PMMA material on the mechanical properties of blends SR/PMMA at different loading level (5%, 10%, 15% and 20%) of PMMA to silicone rubber. FTIR test and some mechanical properties such as tensile strength, elastic modulus, elongation percentage, hardness, compression strength and roughness were done on the all prepared samples, which are used for maxillofacial prostheses applications. The results showed that the optimum percent of PMMA is 10% that has ideal characteristic. So, this sample may be a promising material to achieve the properties required for maxillofacial prosthetic applications.