Study of the functional role of Bcl-2 family proteins in regulating Ca(2+) signals in apoptotic cells.
- Published Article
Biochemical Society transactions
- Publication Date
Nov 01, 2007
Recently, it was found that Bcl-2 family proteins can affect the apoptotic process by modifying Ca(2+) released from the ER (endoplasmic reticulum). In this review, we summarize the evidence that Bcl-2 and Bax can modulate Ca(2+) mobilization from the ER to the cytosol and mitochondria. We also found evidence that both Bcl-2 and Bax can interact with IP(3)Rs (InsP(3) receptors) to modify the Ca(2+) efflux from the ER. On the basis of our findings, we suggest that Bax may interact with IP(3)Rs to facilitate the release of Ca(2+) from the ER during apoptosis.
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This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/17956272