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A study of experimental sinusitis in rabbits.

Authors
Type
Published Article
Journal
Auris Nasus Larynx
0385-8146
Publisher
Elsevier
Publication Date
Volume
8
Issue
2
Pages
87–97
Identifiers
PMID: 7337591
Source
Medline
License
Unknown

Abstract

Sinusitis was experimentally induced in rabbits by injecting one ml of casitone semi-liquid agar containing Staphylococcus aureus 209P in the order of 10(7) per ml into rabbit's bilateral paranasal sinuses (which had been sensitized with a 2.5% concentration of a purified egg white albumin solution) through a percutaneous route with a sterilized syringe. Two weeks after the last injection the rabbits were sacrificed and dissected. Light microscopic (LM) and scanning electron microscopic (SEM) examination of pathomorphological changes in this experimental model revealed that chronic inflammation developed in the mucous membranes of the paranasal sinuses at a high incidence.

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