[Study on cadmium-induced hepatocellular apoptosis in rats].
Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430030, China.
- Published Article
Wei sheng yan jiu = Journal of hygiene research
- Publication Date
The effect of cadmium chloride on hepatocellular apoptosis in rats was studied in vivo at the doses of 5, 10 and 20 mumol/kg by using TUNEL (TdT-mediated dUTP Nick End Labelling), DNA ladder electrophoresis and flow cytometry. The results showed that TUNEL-positive cells could be detected in cadmium-treated rat liver cells. DNA fragmentation (ladder pattern) in cadmium-treated liver cells could be displayed by agarose gel electrophoresis. The rates of apoptotic cells in the liver of cadmium-treated rats at these doses were higher than those of control rats significantly. It was suggested that cadmium chloride could induce hepatocellular apoptosis of rats at certain doses in vivo.
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This record was last updated on 07/08/2017 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12561589