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[The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region].

Authors
  • Baturin, A K
  • Sorokina, E Yu
  • Pogozheva, A V
  • Peskova, E V
  • Makurina, O N
  • Tutelyan, V A
Type
Published Article
Journal
Voprosy pitaniia
Publication Date
Jan 01, 2015
Volume
84
Issue
1
Pages
44–49
Identifiers
PMID: 26402942
Source
Medline
License
Unknown

Abstract

1112 people from Moscow region have been surveyed. Genotyping of rs659366 polymorphism UCP2 gene was performed using allele-specific amplification, result detection in real time and using TaqMan-probes complementary DNA polymorphic sites. The study of rs659366 polymorphism of the UCP2 gene has showed that 36.9% of patients had genotype AA, 46.7%--genotype AG, and 16.5%--genotype GG. The frequency of allele A was 60.2%, allele G--39.8%. BMI, value of fat mass, visceral fat area, serum glucose and triglyceride levels were significantly higher in carriers of A allele in the homozygous and heterozygous state than in carriers of G allele in the homozygous state. Frequency of A allele compared with G allele in obese patients (BMI greater than 30 kg/m2) was: OR--1.52; CI (1.24-1.86), p = 0.001, and in diabetes mellitus type 2--OR--1.22; CI (0.910-1.622), p = 0.19.

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