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Study of the association between histo-blood group antigens and norovirus infection in Chinese children

Authors
  • Zhuang, Zhu-lun1
  • Jin, Yu1
  • Yan, Kun-long1
  • Cheng, Wei-xia1
  • 1 Children’s Hospital of Nanjing Medical University, Nanjing, 210008, China , Nanjing (China)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Jul 24, 2017
Volume
162
Issue
11
Pages
3511–3515
Identifiers
DOI: 10.1007/s00705-017-3494-y
Source
Springer Nature
License
Yellow

Abstract

Human caliciviruses (HuCVs) have been recognized as a major cause of sporadic viral diarrhea in children, among which norovirus genotype GII.4 is the most prevalent genotype. Stool and saliva samples were collected from 295 children with acute diarrhea and 150 asymptomatic children at a hospital in China. The HuCV detection rate was 10.85% (32/295) among the children with acute diarrhea, and all of these 32 children were either HBGA secretors (12/32) or partial secretors (20/32). HuCV was detected in two (1.33%) of the 150 samples obtained from the asymptomatic children. Of the norovirus-GII.3-positive children, 60% had blood type O, but only 17.29% of the symptomatic patients had blood type O, indicating that type O individuals could be at higher risk of GII.3 infection. However, due to the limited number of individuals in this study, further studies with a larger number of subjects should be conducted to verify this hypothesis.

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