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[Studies on the toxicity of polymer of glycolide and lactide(PLGA) and the anti-fertility effect of levonorgestrel(LNG)].

Authors
Type
Published Article
Journal
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Publication Date
Volume
17
Issue
2
Pages
125–128
Identifiers
PMID: 12557762
Source
Medline
License
Unknown

Abstract

PLGA(9:1), a chemical degraded from biomaterials, has been subjected to the tests of acute toxicity, irritations on conjunctiva and muscle, haemolysis in vitro and allergic reaction of mice and rats. The anti-fertility effect of PLGA-LNG microphere composite on the same animals also has been tested. The studies demonstrated that PLGA had fine biological compatibility without side effects such as toxicity, irritations on conjunctiva and muscle, pyrogenicity, haemolysis in vitro and allergic reaction. The contraception period of mice lasted 11.5, 34.6 and 81.2 days respectively after the subcutaneous (s.c.) injection of PLGA-LNG microphere which contains LNG 5, 10 and 20 mg/kg separately. The intramuscular(i.m.) injection of PLGA-LNG microphere containing LNG 13.6, 19.8 and 30 mg/kg respectively could keep the estrus of rats supressed for 76.3, 104.1 and 131.8 days. The injections of PLGA-LNG microphere through s.c. or i.m. showed more significant effects than the same dosages of PLGA-LNG micro-crystal. These results suggest that PLGA-LNG microphere injection has long-term anti-fertility effect.

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