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[Studies on the synthesis of cholecystokinin A receptor antagonists. IV. Synthesis and cholecystokinin A receptor inhibitory activities of benzimidazole derivatives].

Authors
  • 1
  • 1 Central Research Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.
Type
Published Article
Journal
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Publication Date
Volume
116
Issue
9
Pages
735–747
Identifiers
PMID: 8855719
Source
Medline
License
Unknown

Abstract

A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in the compounds having carboxyl or tetrazolyl group. As the most preferred compound, 4-(5,6-dichlorobenzimidazol-2-yl)-N-(3-methoxypropyl)-N-pentylg lutaramic acid (4g) was selected.

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