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Studies on sucrose-palmitate-stearate-containing vesicles encapsulating the cytostatic drug methylglyoxal-bis-guanyl-hydrazone.

Authors
  • Schenk, P
  • Nuhn, P
  • Fichtner, I
  • Arndt, D
Type
Published Article
Journal
Die Pharmazie
Publication Date
Oct 01, 1990
Volume
45
Issue
10
Pages
747–749
Identifiers
PMID: 2089384
Source
Medline
License
Unknown

Abstract

Vesicles prepared from sucrose-palmitate-stearate and cholesterol encapsulating the anticancer drug methylglyoxal-bis-guanylhydrazone, were investigated. Treatment with drug-loaded vesicles of this composition in a q.d. 1-4 schedule resulted for murine leukemias P388 in nearly the same increase in life span as the corresponding dose of the free drug. Even very high dosages of sucrose-palmitase-stearate (up to 480 mg.kg-1.d-1) were tolerated by mice.

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