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Studies on the polymorphism of carbromal.

Authors
  • Kaliszan, R
  • Hać, E
Type
Published Article
Journal
Die Pharmazie
Publication Date
Jul 01, 1976
Volume
31
Issue
7
Pages
453–456
Identifiers
PMID: 10578
Source
Medline
License
Unknown

Abstract

Specimens of carbromal obtained by crystallization from various solvents were analyzed. After a 9-month storage period, the occurrence of three polymorphic forms (I, II and III) was ascertained. The metastable form III obtained by crystallization from dimethylformamide showed a reasonably high stability. Preliminary pharmacological tests revealed clear-cut differences in the therapeutic effect between a commercial specimen and the polymorphic modification III. The results presented here indicate the importance of polymorphism of carbromal for medicinal use.

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