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[Studies on the pharmacokinetics of hexobendine in rats / 2nd communication: Elimination following i.v. administration (author's transl)].

Authors
  • Kolassa, N
  • Dörr, B
  • Pfleger, K
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Oct 01, 1975
Volume
25
Issue
10
Pages
1567–1570
Identifiers
PMID: 1243039
Source
Medline
License
Unknown

Abstract

The elimination of 14C and of 3H was studied in rats after i.v. administration of 0.22--0.33 mg/kg of 14C- or 0.67 mg/kg of 3H-labelled N,N'-dimethyl-N,N'-bis-[3-(3',4',5'-trimethoxy-benzoxy)-propyl]-ethylenediamine-dihydrochloride (hexobendine, Ustimon, Reoxyl), respectively. Regarding the obtained results shortcomings in methods are discussed which may falsify the elimination pattern of radioactively labelled substances. Under certain experimental conditions (closed metabolism chamber with absorption of CO2 or H2O, respectively) 99-100% of the administered radioactivity were detected in the excretion products. The appearance of 14CO2 in the expired air was prevented when the bile duct was cannulated and the bile was drained to the outside before reaching the gut with its probably decarboxylating bacteria.

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