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Studies of murine systemic autoimmunity

Authors
  • Cohen, Philip L.1
  • 1 University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA, 19104 , Philadelphia
Type
Published Article
Journal
Immunologic Research
Publisher
Humana Press
Publication Date
Jun 01, 2003
Volume
27
Issue
2-3
Pages
179–184
Identifiers
DOI: 10.1385/IR:27:2-3:179
Source
Springer Nature
Keywords
License
Yellow

Abstract

Systemic autoimmunity is an important clinical problem, offering a window into fundamental questions of self-nonself tolerance. We have used cellular immunology, serology, and immunopathology to approach several spontaneous mouse models. Although much remains to be done, a picture is emerging of pathological antigen-driven immune responses to self nuclear antigens, highly dependent an multiple genes, and susceptible to abnormalities of apoptosis.

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