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Studies of mouse polyoma virus infection. IV. Evidence for mucoprotein erythrocyte receptors in polyoma virus hemagglutination.

Authors
  • HARTLEY, J W
  • ROWE, W P
  • CHANOCK, R M
  • ANDREWS, B E
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Jul 01, 1959
Volume
110
Issue
1
Pages
81–91
Identifiers
PMID: 13664870
Source
Medline
Keywords
License
Unknown

Abstract

Treatment of guinea pig erythrocytes with types A and B influenza viruses rendered them inagglutinable by polyoma virus; also, the inhibitory effect of ovomucin on polyoma virus hemagglutination was destroyed by pretreatment of the ovomucin with various myxoviruses. These results indicate that polyoma virus and myxovirus erythrocyte receptor sites are identical. However, no destruction by polyoma virus of its own or of myxovirus receptors or inhibitors was detected. No serologic relationship was detected between polyoma virus and members of the myxovirus group; differences in size and stability further indicate their distinctness. No evidence was found of biologic or serologic relationship of polyoma virus with encephalomyocarditis virus or mouse encephalomyelitis virus.

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