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Studies on long-acting aryl carboxylic acid esters of testosterone.

Authors
  • Leung, S L
  • Becker, G
  • Karunanithy, R
  • Low, K F
  • Fell, J T
Type
Published Article
Journal
Pharmaceutica acta Helvetiae
Publication Date
Jan 01, 1989
Volume
64
Issue
4
Pages
121–124
Identifiers
PMID: 2726992
Source
Medline
License
Unknown

Abstract

A series of aryl carboxylic acid esters of testosterone have been synthesized as possible agents for long-acting steroid therapy. The solubilities, partition coefficients and hydrolysis rate constants of the compounds have been determined. The results show that the partition coefficients increase with increasing chain length and are in keeping with calculated values. The hydrolysis rates decrease with increasing chain length except for the first member of the series (benzoate ester) which exhibits the slowest rate, possibly due to the hydrolytic attack being hindered by steric and electronic effects.

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