Studies on liver toxicants. Mixed-function oxidase activities and hemoprotein contents in livers of rats poisoned with bromobenzene.
- Published Article
Archives of toxicology
- Publication Date
Jan 01, 1987
In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene, the activities of a series of drug-metabolizing mixed-function oxidases, i.e., ketamine and aminopyrine N-demethylases, methylayapanine and methoxybiphenyl O-demethylases, and ethoxycoumarin O-deethylase, as well as glutathione and cytochrome b5 contents were found to be decreased, whereas the activities of microsomal, NADPH-dependent cytochrome c and neotetrazolium reductases as well as cytochrome P-450 were unchanged.
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This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3619632