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Studies on liver toxicants. Mixed-function oxidase activities and hemoprotein contents in livers of rats poisoned with bromobenzene.

Authors
  • Beyhl, F E
  • Mayer, D G
Type
Published Article
Journal
Archives of toxicology
Publication Date
Jan 01, 1987
Volume
60
Issue
1-3
Pages
109–111
Identifiers
PMID: 3619632
Source
Medline
License
Unknown

Abstract

In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene, the activities of a series of drug-metabolizing mixed-function oxidases, i.e., ketamine and aminopyrine N-demethylases, methylayapanine and methoxybiphenyl O-demethylases, and ethoxycoumarin O-deethylase, as well as glutathione and cytochrome b5 contents were found to be decreased, whereas the activities of microsomal, NADPH-dependent cytochrome c and neotetrazolium reductases as well as cytochrome P-450 were unchanged.

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