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Studies on influenza infection in ferrets by means of fluorescein-labelled antibody. II. The role of soluble antigen in nuclear fluorescence and cross-reactions.

Authors
  • LIU, C
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Jun 01, 1955
Volume
101
Issue
6
Pages
677–686
Identifiers
PMID: 14367688
Source
Medline
Keywords
License
Unknown

Abstract

Yellow-green fluorescence representing viral antigens was detected in both the nucleus and cytoplasm of epithelial cells of the respiratory tract in ferrets infected with influenza virus. This nuclear fluorescence was the chief manifestation of cross-fluorescent staining reactions among three strains of influenza A virus studied, PR8, Farrington, and Fm(1). Absorption experiments with influenza viral V and soluble S antigens showed that S antigen was responsible for the presence of fluorescence in the nucleus and for the cross-staining reactions among these strains.

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