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Studies on bradykinin potentiating peptide (BPP) from venom of Zhejiang pit viper (Agkistrodon halys pallas)--relationship between structure and function of BPP.

Authors
  • Wang, M Y
  • Luo, S S
  • Qi, Z W
Type
Published Article
Journal
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences / Chung-kuo k'o hsüeh yüan, chu pan
Publication Date
Jul 01, 1983
Volume
26
Issue
7
Pages
716–724
Identifiers
PMID: 6635651
Source
Medline
License
Unknown

Abstract

The structure of the bradykinin potentiating peptide component BPP1 from a 70% methanol extract of the lyophilized powder of pit viper from Zhejiang Province is shown as follows: (formula see text) When the pyroglutamyl residue was removed by pyroglutamate aminopeptidase, the activity of BPP1 was enhanced two-fold but decreased gradually during the course of Edman degradation. The above facts show that the structure integrity of the C-terminal is absolutely necessary for the activity of BPP1.

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